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The Tottenham defender scored on two occasions as Tottenham extended their unbeaten run on the road in the Premier League and delivered the Toffees their initial loss at Hill Dickinson Stadium.

The Toffees were unbeaten in their last five matches at their recently opened stadium at the dockside location, having left their historic home behind after 133 years at the conclusion of the previous campaign.

But Spurs captain the Dutchman pounced twice from set-pieces in the first half to put their impressive record at jeopardy, and they were unable to mount a comeback before the midfielder - assisted by former Toffees attacker the Brazilian - nodded in a final goal to seal the victory.

The Everton defender believed he had levelled the scores five minutes after Van de Ven's opener, directing a powerful header past the Spurs keeper from an Everton corner.

The Portuguese striker, meanwhile, failed to convert a number of opportunities, while Vicario made a series of excellent saves to ensure the London club went five matches on the road without defeat in the English top flight.

But the VAR intervened, advising Craig Pawson to review the score on the screen and the referee ruled that Jack Grealish and the attacker were in offside positions and had interfered with the Spurs keeper.

The win elevates Thomas Frank's side into third place in the Premier League, a handful of points off local foes and leaders Arsenal.

Everton remain 14th and sit six points clear of the relegation zone.

Spurs breakdown: The defender fulfils role at both ends of the field

Following a drab weekday performance in the Champions League against the French side, where they mustered a mere two shots on target, Frank opted for Randal Kolo Muani up front instead of ex-Everton forward the Brazilian.

The summer signing was unable to influence the game before being replaced for Richarlison after an hour on the pitch, but it turns out he proved unnecessary in the final outcome.

Defender Van de Ven converted into an offensive threat to be reckoned with.

Spurs' opening strike came from a well-worked set-piece play, with Rodrigo Bentancur heading the ball toward the six-yard box for an free the defender to head home.

And the captain - filling in as skipper in the Argentine's absence - notched his next goal in added time as he rose above Jordan Pickford to head home.

The Dutchman was equally outstanding in defensive duties, combining well with Kevin Danso as the pair handled superbly with the 34 crosses thrown their way by the opposition.

Everton analysis: Toffees missing finishing touch

Everton's recent stadium had been a fortress, but it seems the novelty may have worn off slightly and fans flocked to the gates after the midfielder's third for Spurs.

The end in Everton's winning streak at home will not be a massive worry for the manager, but their attacking woes are.

The forward and Thierno Barry - the Everton's two established strikers - had scored just a single goal between them before the weekend's outing.

And they were unable to add to that miserable tally on a wet and gloomy night on in Liverpool.

The striker's performance was epitomized when he chose to overhead kick a golden opportunity from close range, despite having room and time to reposition for a simpler shot that would have tested Vicario.

The substitute, as well, failed to influence the game after replacing Beto in the second half.

It wasn't for a shortage of opportunity. The majority of Everton's offensive moves came through the winger and the forward, who relentlessly whipped threatening crosses into the Tottenham box.

Upcoming fixtures for both teams?

The Toffees: Moyes' men travel to the Stadium of Light in the Premier League on early November at 20:00 GMT.

Spurs: Spurs travel to St James' Park on Wednesday, 29 October for their fourth-round League Cup match against Newcastle.